Ontology highlight
ABSTRACT:
SUBMITTER: Astolfi A
PROVIDER: S-EPMC3960194 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Astolfi Annalisa A Vendemini Francesca F Urbini Milena M Melchionda Fraia F Masetti Riccardo R Franzoni Monica M Libri Virginia V Serravalle Salvatore S Togni Marco M Paone Giuseppina G Montemurro Luca L Bressanin Daniela D Chiarini Francesca F Martelli Alberto M AM Tonelli Roberto R Pession Andrea A
Oncotarget 20140101 1
MYCN is an oncogene frequently overexpressed in pediatric solid tumors whereas few evidences suggest his involvement in the pathogenesis of haematologic malignancies. Here we show that MYCN is overexpressed in a relevant proportion (40 to 50%) of adult and pediatric T-cell acute lymphoblastic leukemias (T-ALL). Focusing on pediatric T-ALL, MYCN-expressing samples were found almost exclusively in the TAL1-positive subgroup. Moreover, TAL1 knockdown in T-ALL cell lines resulted in a reduction of M ...[more]