Cannabis alters epigenetic integrity and endocannabinoid signalling in the human follicular niche.
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ABSTRACT:
SUBMITTER: Fuchs Weizman N
PROVIDER: S-EPMC8213445 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Cannabis alters epigenetic integrity and endocannabinoid signalling in the human follicular niche.
Fuchs Weizman Noga N Wyse Brandon A BA Szaraz Peter P Defer Miranda M Jahangiri Sahar S Librach Clifford L CL
Human reproduction (Oxford, England) 20210601 7
<h4>Study question</h4>Do phytocannabinoids (PCs) affect follicular endocannabinoid signalling and the epigenome in the surrounding granulosa cells (GCs)?<h4>Summary answer</h4>Exposure to PCs increases the expression of endocannabinoid receptors and reduces DNA methylation enzyme expression and global DNA methylation in naïve GCs.<h4>What is known already</h4>Cannabis plant derivatives, known as PCs, are used for medicinal and recreational purposes. The main PC, tetrahydrocannabinol (THC), is t ...[more]
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