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Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station.

ABSTRACT: Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation.

SUBMITTER: Wong CP

PROVIDER: S-EPMC8213760 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Behavior of mice aboard the International Space Station.

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Successful amplification of DNA aboard the International Space Station.

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Real-time quantitative PCR analysis of human cardiovascular progenitor cells flown aboard the International Space Station

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-07-26 | GSE110563 | GEO

Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties.

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Real-time quantitative PCR analysis of human cardiovascular progenitor cells flown aboard the International Space Station [miRNA]

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Real-time quantitative PCR analysis of human cardiovascular progenitor cells flown aboard the International Space Station [conventional RT-PCR]

Project description:Adult and neonatal human cardiovacular progenitor cell clonal populations were flown aboard the ISS for 12 days prior to fixation in RNAprotect. Gene expression analysis was performed against clone- and passage-matched ground control samples.

2018-07-26 | GSE110562 | GEO

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