Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified a number of genetic variants for Alzheimer's disease (AD). However, most GWAS were conducted in individuals of European ancestry, and non-European populations are still underrepresented in genetic discovery efforts. Here, we performed GWAS to identify single nucleotide polymorphisms (SNPs) associated with amyloid β (Aβ) positivity using a large sample of Korean population.

Methods

One thousand four hundred seventy-four participants of Korean ancestry were recruited from multicenters in South Korea. Discovery dataset consisted of 1190 participants (383 with cognitively unimpaired [CU], 330 with amnestic mild cognitive impairment [aMCI], and 477 with AD dementia [ADD]) and replication dataset consisted of 284 pa

SUBMITTER: Kim HR 

PROVIDER: S-EPMC8215820 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature