Ontology highlight
ABSTRACT:
SUBMITTER: Stuber JC
PROVIDER: S-EPMC8217238 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Stüber Jakob C JC Richter Christian P CP Bellón Junel Sotolongo JS Schwill Martin M König Iwo I Schuler Benjamin B Piehler Jacob J Plückthun Andreas A
Communications biology 20210621 1
Overexpression of the receptor tyrosine kinase HER2 plays a critical role in the development of various tumors. Biparatopic designed ankyrin repeat proteins (bipDARPins) potently induce apoptosis in HER2-addicted breast cancer cell lines. Here, we have investigated how the spatiotemporal receptor organization at the cell surface is modulated by these agents and is distinguished from other molecules, which do not elicit apoptosis. Binding of conventional antibodies is accompanied by moderate redu ...[more]