Ontology highlight
ABSTRACT:
SUBMITTER: Machen AJ
PROVIDER: S-EPMC8219829 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Machen Alexandra J AJ Fisher Mark T MT Freudenthal Bret D BD
Scientific reports 20210622 1
Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell. Structural details of the translocation process have remained elusive despite their biological importance. To overcome the technical challenges of studying translocation intermediates, we developed a method to immobilize, transition, and stabiliz ...[more]