Project description:Given the interest in the COVID mRNA vaccines, we sought to investigate how the RNA modification N1-methylpseudouridine (and its related modification, pseudouridine) is read by ribosomes and reverse transcriptases. By looking at reverse transcriptase data, we can gain information on how the modification affects duplex stability, which may have important consequences for the tRNA-mRNA interactions found in the ribosome.

2021-10-25 | GSE186464 | GEO

N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

Project description:The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest in the COVID mRNA vaccines, we sought to investigate how N1-methylpseudouridine (and the related modification pseudouridine) is read by ribosomes.

2022-08-18 | PXD029291 | Pride

Obstetric Management of COVID-19 in Pregnant Women.

Project description: Not available

| S-EPMC7264107 | biostudies-literature

COVID-19: Consequences on pregnant women and neonates.

Project description: Not available

| S-EPMC9295334 | biostudies-literature

mRNA vaccines for COVID-19: what, why and how.

Project description: Not available

| S-EPMC8071766 | biostudies-literature

Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19.

Project description: Not available