Ontology highlight
ABSTRACT:
SUBMITTER: Driscoll RK
PROVIDER: S-EPMC8221292 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Driscoll Riley K RK Krasniewski Linda K LK Cockey Samuel G SG Yang Jen-Hao JH Piao Yulan Y Lehrmann Elin E Zhang Yongqing Y Michel Marc M Noh Ji Heon JH Cui Chang-Yi CY Gorospe Myriam M
Aging 20210602 11
GRSF1 is a mitochondrial RNA-binding protein important for maintaining mitochondrial function. We found that GRSF1 is highly expressed in cultured skeletal myoblasts differentiating into myotubes. To understand the physiological function of GRSF1 <i>in vivo</i>, we generated mice in which GRSF1 was specifically ablated in skeletal muscle. The conditional knockout mice (Grsf1cKO) appeared normal until 7-9 months of age. Importantly, however, a reduction of muscle endurance compared to wild-type c ...[more]