Unknown

Dataset Information

0

Inflammasome genes polymorphisms may influence the development of hepatitis C in the Amazonas, Brazil.

ABSTRACT: Hepatitis C is considered a major public health problem caused by the hepatitis C virus (HCV). Viral infections are known to induce production of IL1β through the signaling pathway of inflammasomes. Emerging evidences suggest that Inflammasome genes may influence the immune response against HCV as the host genetic background may contribute to the balance between acute and chronic inflammation. We investigated in 151 patients with chronic hepatitis C and 206 healthy blood donors' individuals (HD). Polymorphisms in the IL1B and IL18 genes were genotyped by PCR-RFLP, while NLRP3, CARD8, CTSB and AIM2 by RT- PCR. Serum assay of IL-1β cytokine was performed by ELISA. 84 patients presented mild fibrosis (

SUBMITTER: Toro DM 

PROVIDER: S-EPMC8221483 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Hepatitis C is considered a major public health problem caused by the hepatitis C virus (HCV). Viral infections are known to induce production of IL1β through the signaling pathway of inflammasomes. Emerging evidences suggest that Inflammasome genes may influence the immune response against HCV as the host genetic background may contribute to the balance between acute and chronic inflammation. We investigated in 151 patients with chronic hepatitis C and 206 healthy blood donors' individuals (HD)  ...[more]

Similar Datasets

Unknown Inflammasome Genes' Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment.
| S-EPMC6343134 | biostudies-literature
Unknown Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil.
| S-EPMC4479602 | biostudies-literature
Unknown Human Orthobunyavirus Infections, Tefe, Amazonas, Brazil.
| S-EPMC5878103 | biostudies-literature
Unknown Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil.
| S-EPMC6687158 | biostudies-literature
Unknown Neisseria meningitidis disease-associated clones in Amazonas State, Brazil.
| S-EPMC6120802 | biostudies-literature
Unknown Miconia papillosperma (Melastomataceae, Miconieae): a new species from Amazonas, Brazil.
| S-EPMC4956926 | biostudies-literature
Unknown Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil.
| S-EPMC3040821 | biostudies-literature
Unknown Social characterization of COVID-19 in the state of Amazonas, Brazil
| S-EPMC9185070 | biostudies-literature
Unknown Complete genome of a dengue virus serotype 4 strain from Amazonas, Brazil.
| S-EPMC4750455 | biostudies-literature
Unknown Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility.
| S-EPMC6980600 | biostudies-literature