Ontology highlight
ABSTRACT:
SUBMITTER: Cerezo EL
PROVIDER: S-EPMC8224940 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Cerezo Emilie L EL Houles Thibault T Lié Oriane O Sarthou Marie-Kerguelen MK Audoynaud Charlotte C Lavoie Geneviève G Halladjian Maral M Cantaloube Sylvain S Froment Carine C Burlet-Schiltz Odile O Henry Yves Y Roux Philippe P PP Henras Anthony K AK Romeo Yves Y
PLoS genetics 20210614 6
Ribosome biogenesis lies at the nexus of various signaling pathways coordinating protein synthesis with cell growth and proliferation. This process is regulated by well-described transcriptional mechanisms, but a growing body of evidence indicates that other levels of regulation exist. Here we show that the Ras/mitogen-activated protein kinase (MAPK) pathway stimulates post-transcriptional stages of human ribosome synthesis. We identify RIOK2, a pre-40S particle assembly factor, as a new target ...[more]