Ontology highlight
ABSTRACT:
SUBMITTER: Gulen B
PROVIDER: S-EPMC4753503 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Gulen Burak B Petrov Anton S AS Okafor C Denise CD Vander Wood Drew D O'Neill Eric B EB Hud Nicholas V NV Williams Loren Dean LD
Scientific reports 20160215
The domain architecture of a large RNA can help explain and/or predict folding, function, biogenesis and evolution. We offer a formal and general definition of an RNA domain and use that definition to experimentally characterize the rRNA of the ribosomal small subunit. Here the rRNA comprising a domain is compact, with a self-contained system of molecular interactions. A given rRNA helix or stem-loop must be allocated uniquely to a single domain. Local changes such as mutations can give domain-w ...[more]