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Targeted Approaches to T-Cell Lymphoma.

ABSTRACT: The T-cell lymphomas are a rare group of Non-Hodgkin's lymphomas derived from mature T-lymphocytes. They are divided broadly into the Peripheral T-cell lymphomas and the Cutaneous T-cell lymphomas. Clinical outcomes vary widely but are generally unsatisfactory with current treatments. The development of an understanding of the various critical pathways in T-cell lymphogenesis and subsequent identification of therapeutic targets has led to a rapid expansion of the previously underwhelming T-cell lymphoma armament. This review aims to provide an up-to-date overview of the current state of targeted therapies in the T-cell lymphomas, including novel antibody-based treatments, small molecule inhibitors and immune-based therapies.

SUBMITTER: Harrop S

PROVIDER: S-EPMC8229513 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Targeted Approaches to T-Cell Lymphoma.

Harrop Sean S Abeyakoon Chathuri C Van Der Weyden Carrie C Prince H Miles HM

Journal of personalized medicine 20210527 6

The T-cell lymphomas are a rare group of Non-Hodgkin's lymphomas derived from mature T-lymphocytes. They are divided broadly into the Peripheral T-cell lymphomas and the Cutaneous T-cell lymphomas. Clinical outcomes vary widely but are generally unsatisfactory with current treatments. The development of an understanding of the various critical pathways in T-cell lymphogenesis and subsequent identification of therapeutic targets has led to a rapid expansion of the previously underwhelming T-cell ...[more]

PMID: 34072040

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