Unknown

Dataset Information

0

Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain.


ABSTRACT: APE1 (DNA (apurinic/apyrimidinic site) endonuclease 1) is a key enzyme of one of the major DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions, acting as a redox regulator of transcription factors and taking part in RNA metabolism. The mechanisms regulating APE1 are still being deciphered. Structurally, human APE1 consists of a well-characterized globular catalytic domain responsible for its endonuclease activity, preceded by a conformationally flexible N-terminal extension, acquired along evolution. This N-terminal tail appears to play a prominent role in the modulation of APE1 and probably in BER coordination. Thus, it is primarily involved in mediating APE1 localization, post-translational modifications, and protein-protein interactions, with all three factors jointly contributing to regulate the enzyme. In this review, recent insights on the regulatory role of the N-terminal region in several aspects of APE1 function are covered. In particular, interaction of this region with nucleophosmin (NPM1) might modulate certain APE1 activities, representing a paradigmatic example of the interconnection between various regulatory factors.

SUBMITTER: Lopez DJ 

PROVIDER: S-EPMC8231204 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9324194 | biostudies-literature
| S-EPMC5322520 | biostudies-literature
| S-EPMC7038996 | biostudies-literature
| S-EPMC3901381 | biostudies-literature
| S-EPMC4552243 | biostudies-literature
| S-EPMC5642108 | biostudies-literature
| S-EPMC2739574 | biostudies-literature
| S-EPMC7672455 | biostudies-literature
| S-EPMC2643816 | biostudies-literature
| S-EPMC4519542 | biostudies-literature