Unknown

Dataset Information

0

Post-myocardial infarction heart failure dysregulates the bone vascular niche.


ABSTRACT: The regulation of bone vasculature by chronic diseases, such as heart failure is unknown. Here, we describe the effects of myocardial infarction and post-infarction heart failure on the bone vascular cell composition. We demonstrate an age-independent loss of type H endothelium in heart failure after myocardial infarction in both mice and humans. Using single-cell RNA sequencing, we delineate the transcriptional heterogeneity of human bone marrow endothelium, showing increased expression of inflammatory genes, including IL1B and MYC, in ischemic heart failure. Endothelial-specific overexpression of MYC was sufficient to induce type H bone endothelial cells, whereas inhibition of NLRP3-dependent IL-1β production partially prevented the post-myocardial infarction loss of type H vasculature in mice. These results provide a rationale for using anti-inflammatory therapies to prevent or reverse the deterioration of bone vascular function in ischemic heart disease.

SUBMITTER: Hoffmann J 

PROVIDER: S-EPMC8233308 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2021-05-13 | E-MTAB-10448 | biostudies-arrayexpress
2021-05-11 | E-MTAB-10432 | biostudies-arrayexpress
| PRJEB44788 | ENA
| PRJEB44933 | ENA
| S-EPMC5561871 | biostudies-literature
| S-EPMC7373908 | biostudies-literature
| S-EPMC3350306 | biostudies-literature
2023-04-13 | GSE229147 | GEO
| S-EPMC4142642 | biostudies-literature
| S-EPMC7547904 | biostudies-literature