Small Molecule Inhibitors of Influenza Virus Entry.
Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC8234048 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Small Molecule Inhibitors of Influenza Virus Entry.
Chen Zhaoyu Z Cui Qinghua Q Caffrey Michael M Rong Lijun L Du Ruikun R
Pharmaceuticals (Basel, Switzerland) 20210618 6
Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon ...[more]
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