Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC8238871 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Chen Daiqin D Liu Shuai S Chen Dinghao D Liu Jinhao J Wu Jerry J Wang Han H Su Yun Y Kwak Gijung G Zuo Xinyuan X Rao Divya D Cui Honggang H Shu Chunying C Suk Jung Soo JS
Angewandte Chemie (International ed. in English) 20210610 28
Inhaled gene therapy poses a unique potential of curing chronic lung diseases, which are currently managed primarily by symptomatic treatments. However, it has been challenging to achieve therapeutically relevant gene transfer efficacy in the lung due to the presence of numerous biological delivery barriers. Here, we introduce a simple approach that overcomes both extracellular and cellular barriers to enhance gene transfer efficacy in the lung in vivo. We endowed tetra(piperazino)fullerene epox ...[more]