The U-shaped association of serum iron level with disease severity in adult hospitalized patients with COVID-19.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that leads to severe respiratory failure (RF). It is known that host exposure to viral infection triggers an iron-lowering response to mitigate pathogenic load and tissue damage. However, the association between host iron-lowering response and COVID-19 severity is not clear. This two-center observational study of 136 adult hospitalized COVID-19 patients analyzed the association between disease severity and initial serum iron, total iron-binding capacity (TIBC), and transferrin saturation (TSAT) levels. Serum iron levels were significantly lower in patients with mild RF than in the non-RF group; however, there were no significant differences in iron levels between the non-RF and severe RF groups, depicting a U-shaped asso

SUBMITTER: Tojo K 

PROVIDER: S-EPMC8238936 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature