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Characterization of T lymphocytes in severe COVID-19 patients.

ABSTRACT: In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.

SUBMITTER: Fenoglio D

PROVIDER: S-EPMC8242373 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Characterization of T lymphocytes in severe COVID-19 patients.

Fenoglio Daniela D Dentone Chiara C Parodi Alessia A Di Biagio Antonio A Bozzano Federica F Vena Antonio A Fabbi Marina M Ferrera Francesca F Altosole Tiziana T Bruzzone Bianca B Giacomini Mauro M Pelosi Paolo P De Maria Andrea A Bassetti Matteo M De Palma Raffaele R Filaci Gilberto G

Journal of medical virology 20210503 9

In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy. ...[more]

PMID: 33913544

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