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The breadth of concomitant virological features in a family cluster outbreak of COVID-19 pneumonia.

ABSTRACT: An outbreak of a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had emerged in 2019 and rapidly posed a global epidemic. Here, we report the breadth of concomitant virological features of a family cluster with COVID-19. The period of virus shedding is significantly different between upper respiratory and feces samples. Even the SARS-CoV-2 virus titers were undetectable in feces, it could be positive again soon and likely related to fluctuated inflammation levels (interleukin-6, etc.) and lowered immune responses (CD4 + T lymphocyte, etc.). Our findings expand the novel understanding of the breadth of concomitant virological features during a non-severe family cluster of COVID-19.

SUBMITTER: Lei G

PROVIDER: S-EPMC8242710 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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The breadth of concomitant virological features in a family cluster outbreak of COVID-19 pneumonia.

Lei Guanglin G Meng Fanping F Wang Cheng C Yan Jin J Sun Fang F Shi Lei L Li Wengang W Luan Junqing J Wang Siyu S Yang Penghui P

Journal of medical virology 20210606 9

An outbreak of a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had emerged in 2019 and rapidly posed a global epidemic. Here, we report the breadth of concomitant virological features of a family cluster with COVID-19. The period of virus shedding is significantly different between upper respiratory and feces samples. Even the SARS-CoV-2 virus titers were undetectable in feces, it could be positive again soon and likely related to flu ...[more]

PMID: 33930189

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