Association of beta-hydroxybutyrate with development of heart failure: Sex differences in a Dutch population cohort.

ABSTRACT:

Background

In the failing heart, energy metabolism is shifted towards increased ketone body oxidation. Nevertheless, the association of beta-hydroxybutyrate (β-OHB) with development of heart failure (HF) remains unclear. We investigated the association between plasma β-OHB and the risk of HF in a prospective population-based cohort.

Design

Plasma β-OHB concentrations were measured in 6134 participants of the PREVEND study. Risk of incident HF with reduced (HFrEF) or preserved (HFpEF) ejection fraction was estimated using multivariable-adjusted Cox regression models.

Results

During median follow-up for 8.2 years, 227 subjects were diagnosed with HF (137 with HFrEF; 90 with HFpEF). Cox regression analyses revealed a significant association of higher β-OHB concentrations

SUBMITTER: Flores-Guerrero JL 

PROVIDER: S-EPMC8244065 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature