Unknown

Dataset Information

0

Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice.


ABSTRACT: Increasing age is the strongest predictor of risk of COVID-19 severity and mortality. Immunometabolic switch from glycolysis to ketolysis protects against inflammatory damage and influenza infection in adults. To investigate how age compromises defense against coronavirus infection, and whether a pro-longevity ketogenic diet (KD) impacts immune surveillance, we developed an aging model of natural murine beta coronavirus (mCoV) infection with mouse hepatitis virus strain-A59 (MHV-A59). When inoculated intranasally, mCoV is pneumotropic and recapitulates several clinical hallmarks of COVID-19 infection. Aged mCoV-A59-infected mice have increased mortality and higher systemic inflammation in the heart, adipose tissue, and hypothalamus, including neutrophilia and loss of γδ T cells in lungs. Activation of ketogenesis in aged mice expands tissue protective γδ T cells, deactivates the NLRP3 inflammasome, and decreases pathogenic monocytes in lungs of infected aged mice. These data establish harnessing of the ketogenic immunometabolic checkpoint as a potential treatment against coronavirus infection in the aged.

SUBMITTER: Ryu S 

PROVIDER: S-EPMC8245129 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8045940 | biostudies-literature
| S-EPMC5605815 | biostudies-literature
2021-07-07 | GSE155348 | GEO
2021-07-07 | GSE155347 | GEO
2021-07-07 | GSE155346 | GEO
| S-EPMC8708337 | biostudies-literature
| S-EPMC9866105 | biostudies-literature
| S-EPMC5629920 | biostudies-literature
| PRJNA649442 | ENA
| S-EPMC5609489 | biostudies-literature