Dataset Information

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

ABSTRACT: Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction, affect longevity and healthspan in C57BL/6 male mice. We find that Cyclic KD, KD alternated weekly with the Control diet to prevent obesity, reduces midlife mortality but does not affect maximum lifespan. A non-ketogenic high-fat diet (HF) fed similarly may have an intermediate effect on mortality. Cyclic KD improves memory performance in old age, while modestly improving composite healthspan measures. Gene expression analysis identifies downregulation of insulin, protein synthesis, and fatty acid synthesis pathways as mechanisms common to KD and HF. However, upregulation of PPAR? target genes is unique to KD, consistent across tissues, and preserved in old age. In all, we show that a non-obesogenic ketogenic diet improves survival, memory, and healthspan in aging mice.

SUBMITTER: Newman JC

PROVIDER: S-EPMC5605815 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

Newman John C JC Covarrubias Anthony J AJ Zhao Minghao M Yu Xinxing X Gut Philipp P Ng Che-Ping CP Huang Yu Y Haldar Saptarsi S Verdin Eric E

Cell metabolism 20170901 3

Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction, affect longevity and healthspan in C57BL/6 male mice. We find that Cyclic KD, KD alternated weekly with the Control diet to prevent obesity, reduces midlife mortality but does not affect maximum lifespan. A non-ketogenic high-fat diet (HF) fed similarly ma ...[more]

PMID: 28877458

Similar Datasets

Project description:OBJECTIVEFew have characterized cognitive changes with age as a function of menopausal stage relative to men, or sex differences in components of memory in early midlife. The study aim was to investigate variation in memory function in early midlife as a function of sex, sex steroid hormones, and reproductive status.METHODSA total of 212 men and women aged 45 to 55 were selected for this cross-sectional study from a prenatal cohort of pregnancies whose mothers were originally recruited in 1959 to 1966. They underwent clinical and cognitive testing and hormonal assessments of menopause status. Multivariate general linear models for multiple memory outcomes were used to test hypotheses controlling for potential confounders. Episodic memory, executive function, semantic processing, and estimated verbal intelligence were assessed. Associative memory and episodic verbal memory were assessed using Face-Name Associative Memory Exam (FNAME) and Selective Reminding Test (SRT), given increased sensitivity to detecting early cognitive decline. Impacts of sex and reproductive stage on performance were tested.RESULTSWomen outperformed men on all memory measures including FNAME (??=?-0.30, P < 0.0001) and SRT (??=?-0.29, P?<?0.0001). Furthermore, premenopausal and perimenopausal women outperformed postmenopausal women on FNAME (initial learning, ?= 0.32, P?=?0.01) and SRT (recall, ?= 2.39, P?=?0.02). Across all women, higher estradiol was associated with better SRT performance (recall, ??=?1.96, P?=?0.01) and marginally associated with FNAME (initial learning, ??=?0.19, P?=?0.06).CONCLUSIONSThis study demonstrated that, in early midlife, women outperformed age-matched men across all memory measures, but sex differences were attenuated for postmenopausal women. Initial learning and memory retrieval were particularly vulnerable, whereas memory consolidation and storage were preserved. Findings underscore the significance of the decline in ovarian estradiol production in midlife and its role in shaping memory function.

Dataset Information

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

Publications

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets