Ontology highlight
ABSTRACT:
SUBMITTER: Pei G
PROVIDER: S-EPMC8246065 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Pei Gang G Zyla Joanna J He Lichun L Moura-Alves Pedro P Steinle Heidrun H Saikali Philippe P Lozza Laura L Nieuwenhuizen Natalie N Weiner January J Mollenkopf Hans-Joachim HJ Ellwanger Kornelia K Arnold Christine C Duan Mojie M Dagil Yulia Y Pashenkov Mikhail M Boneca Ivo Gomperts IG Kufer Thomas A TA Dorhoi Anca A Kaufmann Stefan He SH
The EMBO journal 20210504 13
Cellular stress has been associated with inflammation, yet precise underlying mechanisms remain elusive. In this study, various unrelated stress inducers were employed to screen for sensors linking altered cellular homeostasis and inflammation. We identified the intracellular pattern recognition receptors NOD1/2, which sense bacterial peptidoglycans, as general stress sensors detecting perturbations of cellular homeostasis. NOD1/2 activation upon such perturbations required generation of the end ...[more]