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Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic-bomb survivors.


ABSTRACT: Red blood cell distribution width (RDW), which generally increases with age, is a risk marker for morbidity and mortality in various diseases. We investigated the association between elevated RDW and prior radiation exposure by examining longitudinal RDW changes in 4204 atomic-bomb survivors over 15 years. A positive association was found between RDW and radiation dose, wherein RDW increased by 0·18%/Gy. This radiation-associated effect increased as the participants aged. Elevated RDW was also associated with higher all-cause mortality. The biological mechanisms underlying these observed associations merit further investigation.

SUBMITTER: Yoshida K 

PROVIDER: S-EPMC8247336 | biostudies-literature |

REPOSITORIES: biostudies-literature

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