Clinical relevance of partial HPV16/18 genotyping in stratifying HPV-positive women attending routine cervical cancer screening: a population-based cohort study.

ABSTRACT:

Objective

To evaluate partial HPV16/18 genotyping as a possible biomarker to select women attending HPV-based cervical cancer screening at higher risk to be referred to colposcopy.

Design

Population-based cohort study.

Setting

Organised cervical cancer screening programmes (Italy).

Population

Women with high-risk HPV infection (period: 2015-2019).

Methods

We analysed the association between partial HPV16/18 genotyping, cytology triage and histologically confirmed diagnosis of high-grade cervical intraepithelial neoplasia (CIN3⁺ ) lesions.

Main outcome measures

Detection rate (DR) and positive predictive value (PPV) for histologically confirmed CIN3⁺ (any episode in the 2 years after baseline); sensitivity for CIN3⁺

SUBMITTER: Gori S 

PROVIDER: S-EPMC8248328 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature