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Intermolecular Hydroaminoalkylation of Alkynes.

ABSTRACT: Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl- and dialkylalkynes as well as a terminal alkyne take place with N-benzylanilines, N-alkylanilines, and N-alkylbenzylamines.

SUBMITTER: Kaper T

PROVIDER: S-EPMC8248392 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Intermolecular Hydroaminoalkylation of Alkynes.

Kaper Tobias T Fischer Malte M Thye Hermann H Geik Dennis D Schmidtmann Marc M Beckhaus Ruediger R Doye Sven S

Chemistry (Weinheim an der Bergstrasse, Germany) 20210208 23

Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl- and dialkylalkynes as well as a terminal alkyne take place with N-benzylanilines, N-alkylanilines, and N-alkylbenzylamines. ...[more]

PMID: 33481309

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