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Titanium-Catalyzed Intermolecular Hydroaminoalkylation of Alkenes with Tertiary Amines.

ABSTRACT: The first cationic titanium catalyst system for the intermolecular hydroaminoalkylation of alkenes with various tertiary alkylamines is presented. Corresponding reactions which involve the addition of the α-C-H bond of a tertiary amine across the C-C double bond of an alkene take place at temperatures close to room temperature with excellent regioselectivity to deliver the branched products exclusively. Interestingly, for selected amines, α-C-H bond activation occurs not only at N-methyl but also at N-methylene groups.

SUBMITTER: Geik D

PROVIDER: S-EPMC8251730 | biostudies-literature |

REPOSITORIES: biostudies-literature

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