Multi-morbidity and blood pressure trajectories in hypertensive patients: A multiple landmark cohort study.

ABSTRACT:

Background

Our knowledge of how to better manage elevated blood pressure (BP) in the presence of comorbidities is limited, in part due to exclusion or underrepresentation of patients with multiple chronic conditions from major clinical trials. We aimed to investigate the burden and types of comorbidities in patients with hypertension and to assess how such comorbidities and other variables affect BP levels over time.

Methods and findings

In this multiple landmark cohort study, we used linked electronic health records from the United Kingdom Clinical Practice Research Datalink (CPRD) to compare systolic blood pressure (SBP) levels in 295,487 patients (51% women) aged 61.5 (SD = 13.1) years with first recorded diagnosis of hypertension between 2000 and 2014, by type and number

SUBMITTER: Tran J 

PROVIDER: S-EPMC8248714 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature