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Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making.

ABSTRACT: Physiological need states direct decision-making toward re-establishing homeostasis. Using a two-alternative forced choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food seeking when thirsty. These results show limits on interoceptive knowledge of hunger and thirst states to guide decision-making. Instead, need states were identified after food and water consumption by outcome evaluation, which depended on the medial prefrontal cortex.

SUBMITTER: Eiselt AK

PROVIDER: S-EPMC8254795 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making.

Eiselt Anne-Kathrin AK Chen Susu S Chen Jim J Arnold Jon J Kim Tahnbee T Pachitariu Marius M Sternson Scott M SM

Nature neuroscience 20210510 7

Physiological need states direct decision-making toward re-establishing homeostasis. Using a two-alternative forced choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food seeking when thirsty. These results show limits on interoceptive knowledge of hunger and thirst states to guide decision-making. Instead, need states were identified after food and water consumption by outcome evaluation, which ...[more]

PMID: 33972802

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