Ontology highlight
ABSTRACT:
SUBMITTER: Mana MD
PROVIDER: S-EPMC8258630 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Cell reports 20210601 10
Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, and function. Although PPAR (peroxisome proliferator-activated receptor) nuclear receptor activity has been proposed to facilitate these effects, their exact role is unclear. Here we find that, in loss-of-function in vivo models, PPARα and PPARδ contribute to the HFD ...[more]