Dataset Information

Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease.

ABSTRACT:

Background

Plasma biomarkers showed a promising value in the disease diagnosis and management of Alzheimer's disease (AD). However, profiles of the biomarkers and the associations with cognition across a spectrum of cognitive stages have seldom been reported.

Methods

We recruited 320 individuals with cognitive impairment and 131 cognitively normal participants from a memory clinic and a community cohort. Participants were classified into 6 groups based on their Clinical Dementia Rating (CDR) scores and clinical diagnosis, including AD, amnestic mild cognitive impairment (aMCI), and normal cognition (NC). A battery of neuropsychological tests was used to assess the global and domain-specific cognition. Plasma Aβ_1-40, Aβ_1-42, Aβ_1-42/Aβ_1-40, total tau (t-tau), neurofilament protein light chain (NfL), and phosphorylated tau at threonine 181 (p-tau181) were quantified using the single-molecule array (Simoa) platform.

Results

All the plasma markers (Aβ_1-40, Aβ_1-42, Aβ_1-42/Aβ_1-40, t-tau, NfL, p-tau181) showed certain discrepancies among NC, aMCI, and AD groups. The p-tau181 level showed a continuous escalating trend as the CDR scores increased from 0 (NC group) to 3 (severe AD). Compared with other biomarkers, p-tau181 had correlations with broader cognitive domains, covering global cognition (r = -0.536, P < 0.0001), memory (r = -0.481, P < 0.0001), attention (r = -0.437, P < 0.0001), visuospatial function (r = -0.385, P < 0.0001), and language (r = -0.177, P = 0.0003). Among participants with CDR ≥ 1, higher p-tau181 was correlated with worse global cognition (r = -0.301, P < 0.001).

Conclusions

Plasma p-tau181 had correlations with broader cognitive domains, suggesting its potential as a promising clinical-relevant blood-based biomarker.

SUBMITTER: Xiao Z

PROVIDER: S-EPMC8259165 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease.

Xiao Zhenxu Z Wu Xue X Wu Wanqing W Yi Jingwei J Liang Xiaoniu X Ding Saineng S Zheng Li L Luo Jianfeng J Gu Hongchen H Zhao Qianhua Q Xu Hong H Ding Ding D

Alzheimer's research & therapy 20210705 1

<h4>Background</h4>Plasma biomarkers showed a promising value in the disease diagnosis and management of Alzheimer's disease (AD). However, profiles of the biomarkers and the associations with cognition across a spectrum of cognitive stages have seldom been reported.<h4>Methods</h4>We recruited 320 individuals with cognitive impairment and 131 cognitively normal participants from a memory clinic and a community cohort. Participants were classified into 6 groups based on their Clinical Dementia R ...[more]

PMID: 34225797

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Dataset Information

Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease.

Background

Methods

Results

Conclusions

Publications

Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease.

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