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Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C.

ABSTRACT: Switching on kinases: Synthetic caged DAG-lactones have been developed and showed decreases of two orders of magnitude, relative to the corresponding parent compounds, in their binding affinities towards PKC. The caged compounds had no effect on the translocation of PKC until after photoactivation. This approach is a potentially powerful tool for probing the PKC signaling cascade.

SUBMITTER: Nomura W

PROVIDER: S-EPMC8259317 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C.

Nomura Wataru W Narumi Tetsuo T Ohashi Nami N Serizawa Yuki Y Lewin Nancy E NE Blumberg Peter M PM Furuta Toshiaki T Tamamura Hirokazu H

Chembiochem : a European journal of chemical biology 20110118 4

Switching on kinases: Synthetic caged DAG-lactones have been developed and showed decreases of two orders of magnitude, relative to the corresponding parent compounds, in their binding affinities towards PKC. The caged compounds had no effect on the translocation of PKC until after photoactivation. This approach is a potentially powerful tool for probing the PKC signaling cascade. ...[more]

PMID: 22238145

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