Dataset Information

Harmonisation of PET/CT contrast recovery performance for brain studies.

ABSTRACT:

Purpose

In order to achieve comparability of image quality, harmonisation of PET system performance is imperative. In this study, prototype harmonisation criteria for PET brain studies were developed.

Methods

Twelve clinical PET/CT systems (4 GE, 4 Philips, 4 Siemens, including SiPM-based "digital" systems) were used to acquire 30-min PET scans of a Hoffman 3D Brain phantom filled with ~ 33 kBq·mL^-1 [¹⁸F]FDG. Scan data were reconstructed using various reconstruction settings. The images were rigidly coregistered to a template (voxel size 1.17 × 1.17 × 2.00 mm³) onto which several volumes of interest (VOIs) were defined. Recovery coefficients (RC) and grey matter to white matter ratios (GMWMr) were derived for eroded (denoted in the text by subscript e) and non-eroded grey (GM) and white (WM) matter VOIs as well as a mid-phantom cold spot (VOI_cold) and VOIs from the Hammers atlas. In addition, left-right hemisphere differences and voxel-by-voxel differences compared to a reference image were assessed.

Results

Systematic differences were observed for reconstructions with and without point-spread-function modelling (PSF_ON and PSF_OFF, respectively). Normalising to image-derived activity, upper and lower limits ensuring image comparability were as follows: for PSF_ON, RC_GMe = [0.97-1.01] and GMWMr_e = [3.51-3.91] for eroded VOI and RC_GM = [0.78-0.83] and GMWMr = [1.77-2.06] for non-eroded VOI, and for PSF_OFF, RC_GMe = [0.92-0.99] and GMWMr_e = [3.14-3.68] for eroded VOI and RC_GM = [0.75-0.81] and GMWMr = [1.72-1.95] for non-eroded VOI.

Conclusions

To achieve inter-scanner comparability, we propose selecting reconstruction settings based on RC_GMe and GMWMr_e as specified in "Results". These proposed standards should be tested prospectively to validate and/or refine the harmonisation criteria.

SUBMITTER: Verwer EE

PROVIDER: S-EPMC8263427 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:PURPOSE:The objective of this study was to explore the feasibility of harmonising performance for PET/CT systems equipped with time-of-flight (ToF) and resolution modelling/point spread function (PSF) technologies. A second aim was producing a working prototype of new harmonising criteria with higher contrast recoveries than current EARL standards using various SUV metrics. METHODS:Four PET/CT systems with both ToF and PSF capabilities from three major vendors were used to acquire and reconstruct images of the NEMA NU2-2007 body phantom filled conforming EANM EARL guidelines. A total of 15 reconstruction parameter sets of varying pixel size, post filtering and reconstruction type, with three different acquisition durations were used to compare the quantitative performance of the systems. A target range for recovery curves was established such that it would accommodate the highest matching recoveries from all investigated systems. These updated criteria were validated on 18 additional scanners from 16 sites in order to demonstrate the scanners' ability to meet the new target range. RESULTS:Each of the four systems was found to be capable of producing harmonising reconstructions with similar recovery curves. The five reconstruction parameter sets producing harmonising results significantly increased SUVmean (25%) and SUVmax (26%) contrast recoveries compared with current EARL specifications. Additional prospective validation performed on 18 scanners from 16 EARL accredited sites demonstrated the feasibility of updated harmonising specifications. SUVpeak was found to significantly reduce the variability in quantitative results while producing lower recoveries in smaller (?17 mm diameter) sphere sizes. CONCLUSIONS:Harmonising PET/CT systems with ToF and PSF technologies from different vendors was found to be feasible. The harmonisation of such systems would require an update to the current multicentre accreditation program EARL in order to accommodate higher recoveries. SUVpeak should be further investigated as a noise resistant alternative quantitative metric to SUVmax.

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