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Cost-efficient and user-friendly ¹⁷O/¹⁸O labeling procedures of fatty acids using mechanochemistry.

ABSTRACT: Two mechanochemical procedures for 17O/18O-isotope labeling of fatty acids are reported: a carboxylic acid activation/hydrolysis approach and a saponification approach. The latter route allowed first-time enrichment of important polyunsaturated fatty acids (PUFAs) including docosahexaenoic acid (DHA). Overall, a total of 9 pure labeled products were isolated in high yields (≥80%) and with high enrichment levels (≥37% average labeling of C=O and C-OH carboxylic oxygen atoms), under mild conditions, and in short time (

SUBMITTER: Spackova J

PROVIDER: S-EPMC8265319 | biostudies-literature |

REPOSITORIES: biostudies-literature

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