Sodium channel activation underlies transfluthrin repellency in Aedes aegypti.

ABSTRACT:

Background

Volatile pyrethroid insecticides, such as transfluthrin, have received increasing attention for their potent repellent activities in recent years for controlling human disease vectors. It has been long understood that pyrethroids kill insects by promoting activation and inhibiting inactivation of voltage-gated sodium channels. However, the mechanism of pyrethroid repellency remains poorly understood and controversial.

Methodology/principal findings

Here, we show that transfluthrin repels Aedes aegypti in a hand-in-cage assay at nonlethal concentrations as low as 1 ppm. Contrary to a previous report, transfluthrin does not elicit any electroantennogram (EAG) responses, indicating that it does not activate olfactory receptor neurons (ORNs). The 1S-cis isomer of tran

SUBMITTER: Andreazza F 

PROVIDER: S-EPMC8266078 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature