The consequences of a high-calorie diet background before calorie restriction on skeletal muscles in a mouse model.

ABSTRACT: The beneficial effects of calorie restriction (CR) are numerous. However, there is no scientific evidence about how a high-calorie diet (HCD) background influences the mechanisms underlying CR on skeletal muscles in an experimental mouse model. Herein we present empirical evidence showing significant interactions between HCD (4 months) and CR (3 months). Pectoralis major and quadriceps femoris vastus medialis, in the experimental and control groups, displayed metabolic and physiologic heterogeneity and remarkable plasticity, according to the dietary interventions. HCD-CR not only altered genetic activation patterns of satellite SC markers but also boosted the expression of myogenic regulatory factors and key activators of mitochondrial biogenesis, which in turn were also associated

SUBMITTER: Maldonado M 

PROVIDER: S-EPMC8266348 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature