Dataset Information
PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway.
Ontology highlight
ABSTRACT: Background
Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury.Aim
In this study, we explored the potential mechanism of PPARγ in the pathogenesis of hepatic IR injury by mice model.Methods
After treated with si-PPARγ or rosiglitazone, mice were subjected to hepatic ischemia-reperfusion. Liver tissue and blood samples were collected to evaluate liver injury and detected relative mRNA and protein expressions.Results
The expression of PPARγ was increased after reperfusion. And the alleviation of PPARγ aggravated the liver damage in IR; at the same time, upregulation of the expression of PPARγ released the liver damage. And these effects of PPARγ in IR were related to the AMPK/mTOR/autophagy signaling pathway.Conclusion
PPARγ plays an important role in hepatic IR injury at least partly via the AMPK/mTOR/autophagy pathway.
SUBMITTER: Wu L
PROVIDER: S-EPMC8275421 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
PPAR<i>γ</i> Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway.
PPAR research 20210703
<h4>Background</h4>Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPAR<i>γ</i> is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury.<h4>Aim</h4>In this study, we explored the potential mechanism of PPAR<i>γ</i> in the pathogenesis of hepatic IR injury by mice model.<h4>Methods</h4>After treated with si-PPAR<i>γ</i> or rosiglitazone, mice were subjected to hepat ...[more]