Innate antiviral defense demonstrates high energetic efficiency in a bony fish.

ABSTRACT:

Background

Viruses can impose energetic demands on organisms they infect, in part by hosts mounting resistance. Recognizing that oxygen uptake reliably indicates steady-state energy consumption in all vertebrates, we comprehensively evaluated oxygen uptake and select transcriptomic messaging in sockeye salmon challenged with either a virulent rhabdovirus (IHNV) or a low-virulent reovirus (PRV). We tested three hypotheses relating to the energetic costs of viral resistance and tolerance in this vertebrate system: (1) mounting resistance incurs a metabolic cost or limitation, (2) induction of the innate antiviral interferon system compromises homeostasis, and (3) antiviral defenses are weakened by acute stress.

Results

IHNV infections either produced mortality within 1-4 weeks

SUBMITTER: Polinski MP 

PROVIDER: S-EPMC8276435 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature