Ontology highlight
ABSTRACT:
SUBMITTER: Liang Y
PROVIDER: S-EPMC8278126 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Liang Yicheng Y Lei Yangyang Y Du Minjun M Liang Mei M Liu Zixu Z Li Xingkai X Gao Yushun Y
Journal of cellular and molecular medicine 20210611 14
Despite the previous evidence showing that SHC adaptor protein 1 (SHC1) could encode three distinct isoforms (p46SHC, p52SHC and p66SHC) that function in different activities such as regulating life span and Ras activation, the precise underlying role of SHC1 in lung cancer also remains obscure. In this study, we firstly found that SHC1 expression was up-regulated both in lung adenocarcinoma (LUAD) and in lung squamous cell carcinoma (LUSC) tissues. Furthermore, compared to patients with lower S ...[more]