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Allylic alcohol synthesis by Ni-catalyzed direct and selective coupling of alkynes and methanol.


ABSTRACT: Methanol is an abundant and renewable chemical raw material, but its use as a C1 source in C-C bond coupling reactions still constitutes a big challenge, and the known methods are limited to the use of expensive and noble metal catalysts such as Ru, Rh and Ir. We herein report nickel-catalyzed direct coupling of alkynes and methanol, providing direct access to valuable allylic alcohols in good yields and excellent chemo- and regioselectivity. The approach features a broad substrate scope and high atom-, step- and redox-economy. Moreover, this method was successfully extended to the synthesis of [5,6]-bicyclic hemiacetals through a cascade cyclization reaction of alkynones and methanol.

SUBMITTER: Chen H 

PROVIDER: S-EPMC8278963 | biostudies-literature |

REPOSITORIES: biostudies-literature

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