Ontology highlight
ABSTRACT:
SUBMITTER: Chiu HC
PROVIDER: S-EPMC5964026 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20180425 21
Trimethylsilyl (TMS)-protected alkynes served as selective alkyne cross-coupling partners in titanium-catalyzed [2+2+1] pyrrole synthesis. Reactions of TMS-protected alkynes with internal alkynes and azobenzene under the catalysis of titanium imido complexes yielded pentasubstituted 2-TMS-pyrroles with greater than 90 % selectivity over the other nine possible pyrrole products. The steric and electronic effects of the TMS group were both identified to play key roles in this highly selective pyrr ...[more]