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Catalyst-free arylation of sulfonamides via visible light-mediated deamination.

ABSTRACT: A novel arylation of sulfonamides with boronic acids to afford numerous diaryl sulfones via a visible light-mediated N-S bond cleavage other than the typical transition-metal-catalyzed C(O)-N bond activation is described. This methodology, which represents the first catalyst-free protocol for the sulfonylation of boronic acids, is characterized by its simple reaction conditions, good functional group tolerance and high efficiency. Several successful examples for the late-stage functionalization of diverse sulfonamides indicate the high potential utility of this method in pharmaceutical science and organic synthesis.

SUBMITTER: Luo Y

PROVIDER: S-EPMC8279011 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles.

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