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Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst.

ABSTRACT: This report describes a highly enantioselective oxidative sp3 C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C-H asymmetric arylation of THIQs.

SUBMITTER: Querard P 

PROVIDER: S-EPMC5238558 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Copper-catalyzed asymmetric sp<sup>3</sup> C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst.

Querard Pierre P   Perepichka Inna I   Zysman-Colman Eli E   Li Chao-Jun CJ  

Beilstein journal of organic chemistry 20161206

This report describes a highly enantioselective oxidative sp<sup>3</sup> C-H arylation of <i>N</i>-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)<sub>2</sub>(dtbbpy)]PF<sub>6</sub>, and chiral copper catalysts provide a mild and highly effective sp<sup>3</sup> C-H asymmetric arylation of THIQs. ...[more]

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