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Solid-Phase Synthesis of Gly-Ψ[CH(CF3)NH]-Peptides.

ABSTRACT: The solid-phase synthesis of Gly-Ψ[CH(CF3)NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF3)NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.

SUBMITTER: Sgorbati C 

PROVIDER: S-EPMC8279481 | biostudies-literature |

REPOSITORIES: biostudies-literature

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