SARS-CoV-2 Infection in the Immunodeficient Host: Necessary and Dispensable Immune Pathways.

ABSTRACT: Since its outbreak in late December 2019 in Wuhan, coronavirus disease 2019 pandemic has posed a therapeutic challenge for the world population, with a plenty of clinical pictures and a broad spectrum of severity of the manifestations. In spite of initial speculations on a direct role of primary or acquired immune deficiency in determining a worse disease outcome, recent studies have provided evidence that specific immune defects may either serve as an experimentum naturae entailing this risk or may not be relevant enough to impact the host defense against the virus. Taken together, these observations may help unveil pathogenetic mechanisms of the infection and suggest new therapeutic strategies. Thus, in this review, we summarize current knowledge regarding the mechanisms of immune respon

SUBMITTER: Giardino G 

PROVIDER: S-EPMC8279920 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature