Transient gain of function of cannabinoid CB₁ receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes.

ABSTRACT: Here we aimed to unify some previous controversial reports on changes in both cannabinoid CB₁ receptor (CB₁R) expression and glucose metabolism in the forebrain of rodent models of diabetes. We determined how glucose metabolism and its modulation by CB₁R ligands evolve in the frontal cortex of young adult male Wistar rats, in the first 8 weeks of streptozotocin-induced type-1 diabetes (T1D). We report that frontocortical CB₁R protein density was biphasically altered in the first month of T1D, which was accompanied with a reduction of resting glucose uptake ex vivo in acute frontocortical slices that was normalized after eight weeks in T1D. This early reduction of glucose uptake in slices was also restored by ex vivo treatment with both the non-se

SUBMITTER: Pedro JR 

PROVIDER: S-EPMC8281444 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature