Treating Alpelisib-Induced Hyperglycemia with Very Low Carbohydrate Diets and Sodium-Glucose Co-Transporter 2 Inhibitors: A Case Series.
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ABSTRACT:
SUBMITTER: Blow T
PROVIDER: S-EPMC8283040 | biostudies-literature | 2021 Jan-Dec
REPOSITORIES: biostudies-literature
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Treating Alpelisib-Induced Hyperglycemia with Very Low Carbohydrate Diets and Sodium-Glucose Co-Transporter 2 Inhibitors: A Case Series.
Blow Tahj T Hyde Parker N PN Falcone John N JN Neinstein Aaron A Vasan Neil N Chitkara Ritika R Hurd Maurice A MA Sardesai Sagar S Lustberg Maryam B MB Flory James H JH Volek Jeff S JS Goncalves Marcus D MD
Integrative cancer therapies 20210101
Alpelisib is a α-selective phosphatidylinositol 3-kinase (PI3K) inhibitor approved for treatment of postmenopausal women, and men, with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), PIK3CA-mutated, advanced breast cancer (ABC). Hyperglycemia is a common, on-target adverse effect that impairs treatment efficacy and increases the rate of treatment delays, dose reductions, and discontinuation. Currently, there are no clear guidelines on how to manage hy ...[more]
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