Cell type-specific and cross-population polygenic risk score analyses of MIR137 gene pathway in schizophrenia.
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ABSTRACT:
SUBMITTER: Yao Y
PROVIDER: S-EPMC8283158 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Cell type-specific and cross-population polygenic risk score analyses of <i>MIR137</i> gene pathway in schizophrenia.
Yao Yin Y Guo Wei W Zhang Siwei S Yu Hao H Yan Hao H Zhang Hanwen H Sanders Alan R AR Yue Weihua W Duan Jubao J
iScience 20210625 7
Cell type-specific pathway-based polygenic risk scores (PRSs) may better inform disease biology and improve the precision of PRS-based clinical prediction. For <i>microRNA-137</i> (<i>MIR137</i>), a leading neuropsychiatric risk gene and a post-transcriptional master regulator, we conducted a cell type-specific gene set PRS analysis in both European and Han Chinese schizophrenia (SZ) samples. We found that the PRS of neuronal <i>MIR137</i> <i>-</i>target genes better explains SZ risk than PRS de ...[more]
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