Cell type-specific and cross-population polygenic risk score analyses of MIR137 gene pathway in schizophrenia.

ABSTRACT: Cell type-specific pathway-based polygenic risk scores (PRSs) may better inform disease biology and improve the precision of PRS-based clinical prediction. For microRNA-137 (MIR137), a leading neuropsychiatric risk gene and a post-transcriptional master regulator, we conducted a cell type-specific gene set PRS analysis in both European and Han Chinese schizophrenia (SZ) samples. We found that the PRS of neuronal MIR137 -target genes better explains SZ risk than PRS derived from MIR137 -target genes in iPSC or from the reported gene sets showing MIR137 -altered expression. Compared with the PRS derived from the whole genome or the target genes of TCF4, the PRS of neuronal MIR137 -target genes explained a disproport

SUBMITTER: Yao Y 

PROVIDER: S-EPMC8283158 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature