Unknown

Dataset Information

0

The role of leptospiremia and specific immune response in severe leptospirosis.


ABSTRACT: Leptospirosis can cause a high mortality rate, especially in severe cases. This multicenter cross-sectional study aimed to examine both host and pathogen factors that might contribute to the disease severity. A total of 217 leptospirosis patients were recruited and divided into two groups of non-severe and severe. Severe leptospirosis was defined by a modified sequential organ failure assessment (mSOFA) score of more than two or needed for mechanical ventilation support or had pulmonary hemorrhage or death. We found that leptospiremia, plasma neutrophil gelatinase-associated lipocalin (pNGAL), and interleukin 6 (IL-6) at the first day of enrollment (day 1) and microscopic agglutination test (MAT) titer at 7 days after enrollment (days 7) were significantly higher in the severe group than in the non-severe group. After adjustment for age, gender, and the days of fever, there were statistically significant associations of baseline leptospiremia level (OR 1.70, 95% CI 1.23-2.34, p = 0.001), pNGAL (OR 9.46, 95% CI 4.20-21.33, p < 0.001), and IL-6 (OR 2.82, 95% CI 1.96-4.07, p < 0.001) with the severity. In conclusion, a high leptospiremia, pNGAL, and IL-6 level at baseline were associated with severe leptospirosis.

SUBMITTER: Limothai U 

PROVIDER: S-EPMC8285422 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2016-09-10 | GSE86630 | GEO
| S-EPMC3777885 | biostudies-literature
| S-EPMC6391019 | biostudies-literature
| S-EPMC4672444 | biostudies-literature
| S-EPMC3865605 | biostudies-literature
| S-EPMC4736010 | biostudies-literature
| S-EPMC3542117 | biostudies-literature
| S-EPMC6358762 | biostudies-literature
| S-EPMC7682886 | biostudies-literature
| S-EPMC4900524 | biostudies-literature