Myopia in African Americans Is Significantly Linked to Chromosome 7p15.2-14.2.

ABSTRACT:

Purpose

The purpose of this study was to perform genetic linkage analysis and association analysis on exome genotyping from highly aggregated African American families with nonpathogenic myopia. African Americans are a particularly understudied population with respect to myopia.

Methods

One hundred six African American families from the Philadelphia area with a family history of myopia were genotyped using an Illumina ExomePlus array and merged with previous microsatellite data. Myopia was initially measured in mean spherical equivalent (MSE) and converted to a binary phenotype where individuals were identified as affected, unaffected, or unknown. Parametric linkage analysis was performed on both individual variants (single-nucleotide polymorphisms [SNPs] and microsatellites

SUBMITTER: Simpson CL 

PROVIDER: S-EPMC8287048 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature